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首页> 外文OA文献 >Low 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 levels are independently associated with macroalbuminuria, but not with retinopathy and macrovascular disease in type 1 diabetes: the EURODIAB prospective complications study
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Low 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 levels are independently associated with macroalbuminuria, but not with retinopathy and macrovascular disease in type 1 diabetes: the EURODIAB prospective complications study

机译：低25-羟基维生素D2和25-羟基维生素D3水平与大量白蛋白尿独立相关，但与1型糖尿病中的视网膜病变和大血管疾病无关：​​EURODIaB前瞻性并发症研究

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BackgroundLow circulating levels of total vitamin D [25(OH)D] and 25(OH)D3 have been associated with vascular complications in few studies on individuals with type 1 diabetes. However, these measures are affected by UV light exposure. Circulating 25(OH)D2, however, solely represents dietary intake of vitamin D2, but its association with complications of diabetes is currently unknown. We investigated the associations between 25(OH)D2 and 25(OH)D3 and the prevalence of albuminuria, retinopathy and cardiovascular disease (CVD) in individuals with type 1 diabetes.MethodsWe measured circulating 25(OH)D2 and 25(OH)D3 in 532 individuals (40 ± 10 years old, 51 % men) with type 1 diabetes who participated in the EURODIAB Prospective Complications Study. Cross-sectional associations of 25(OH)D2 and 25(OH)D3 with albuminuria, retinopathy and CVD were assessed with multiple logistic regression analyses adjusted for age, sex, season, BMI, smoking, HbA1c, total-HDL-cholesterol-ratio, systolic blood pressure, antihypertensive medication, eGFR, physical activity, alcohol intake, albuminuria, retinopathy and CVD, as appropriate.ResultsFully adjusted models revealed that 1 nmol/L higher 25(OH)D2 and 10 nmol/L higher 25(OH)D3 were associated with lower prevalence of macroalbuminuria with ORs (95 % CI) of 0.56 (0.43;0.74) and 0.82 (0.72;0.94), respectively. These vitamin D species were not independently associated with microalbuminuria, non-proliferative and proliferative retinopathy or CVD.ConclusionsIn individuals with type 1 diabetes, both higher 25(OH)D2 and 25(OH)D3 are associated with a lower prevalence of macroalbuminuria, but not of retinopathy and CVD. Prospective studies are needed to further examine the associations between 25(OH)D2 and 25(OH)D3 and the development of microvascular complications and CVD in type 1 diabetes.
机译：背景在很少的1型糖尿病患者研究中，总维生素D [25（OH）D]和25（OH）D3的低循环水平与血管并发症相关。但是，这些措施会受到紫外线照射的影响。然而，循环中的25（OH）D2仅代表饮食中维生素D2的摄入量，但目前尚不清楚其与糖尿病并发症的相关性。我们调查了1型糖尿病患者中25（OH）D2和25（OH）D3与白蛋白尿，视网膜病变和心血管疾病（CVD）的患病率之间的关系。方法我们测量了25（OH）D2和25（OH）D3的循环参与EURODIAB前瞻性并发症研究的532名1型糖尿病患者（40±10岁，男性51％）。 25（OH）D2和25（OH）D3与白蛋白尿，视网膜病变和CVD的横断面关联性通过针对年龄，性别，季节，BMI，吸烟，HbA1c，总HDL-胆固醇比调整的多元logistic回归分析进行评估，收缩压，降压药物，eGFR，身体活动，酒精摄入，蛋白尿，视网膜病变和CVD（视情况而定）结果完全调整的模型显示，25（OH）D2高1 nmol / L，25（OH）高10 nmol / L D3与大白蛋白尿的患病率较低相关，OR（95％CI）分别为0.56（0.43; 0.74）和0.82（0.72; 0.94）。这些维生素D种类与微量白蛋白尿，非增生性和增生性视网膜病变或CVD无关。不是视网膜病变和CVD。需要进行前瞻性研究，以进一步检查25（OH）D2和25（OH）D3与1型糖尿病微血管并发症和CVD的发展之间的关系。

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